Principal Scientist, Medicinal Chemistry (ADC and Bioconjugation)
Core
Leading the discovery and preclinical development of Antibody-Drug Conjugates (ADCs) and bioconjugates, bridging medicinal chemistry, protein therapeutics, and discovery biology to create novel therapies for viral and inflammatory diseases and cancers.
Role type
Principal Scientist, Medicinal Chemistry (ADC and Bioconjugation)
Builds
Novel ADC candidates and protein bioconjugates for clinical development
Domain
Biopharmaceuticals / Medicinal Chemistry / ADC Development
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
ADC drug discovery leadership, synthetic and medicinal chemistry, linker design and cleavage mechanisms, hydrophilic mask strategies, ADC characterization (SEC, HIC, RPLC, mass spectrometry), high-throughput conjugation automation, enzymatic conjugation methods
Preferred skills
Modern platforms for synthesis/purification/characterization of small molecule/peptide/protein/LNP bioconjugates, project team leadership
Technologies
SEC, HIC, RPLC, high-resolution mass spectrometry, automation platforms
Responsibilities
Identify new opportunities from internal/external pipelines and lead projects to clinical candidate nomination; Develop long-term ADC program strategy and provide guidance to project teams; Evaluate external technologies and assets for diligence; Coordinate design and optimization of payload properties and linker strategies; Expand lab capabilities for protein bioconjugate synthesis and purification; Enable structured data acquisition for ADC modalities; Provide training and technical support on bioconjugation techniques
Seniority
Principal, hands-on IC with strategic leadership