Lead Scientist - Directing Cryo-Electron Microscopy and Tomography Center
Core
Lead scientist directing daily operations, strategic growth, and team management for a Cryo-EM/Cryo-ET center supporting pediatric cancer, infectious disease, neuroscience, and immunology research.
Role type
Senior scientific leader (IC + management)
Builds
Structural biology and cellular imaging projects using state-of-the-art cryo-EM instrumentation and computational infrastructure
Domain
Structural biology / Cryo-electron microscopy
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Scientific leadership, team supervision and mentoring, cryo-EM/Cryo-ET workflow expertise, high-end TEM operation, imaging strategy design, SOP development, vendor coordination, strategic planning
Preferred skills
PhD in Structural Biology/Cell Biology/Biophysics, hands-on Cryo-ET/cryo-FIB/cryo-CLEM experience, familiarity with EPU/SerialEM/RELION/CryoSPARC/Warp, multidisciplinary collaboration
Technologies
Krios G3i, Krios G4, Talos Arctica, Aquilos 2, RELION, CryoSPARC, Warp, EPU, SerialEM, Tomography 5
Responsibilities
Provide scientific and operational leadership for the Cryo-EM/Cryo-ET Center; Supervise and mentor a team of 3-4 staff scientists; Oversee day-to-day operation and scheduling of cryo-EM instrumentation; Ensure high-quality user support for SPA, cryo-ET, cryo-FIB, and cryo-CLEM; Develop and implement training programs for users; Work with investigators to design imaging strategies; Participate in developing emerging methodologies and automation workflows; Collaborate with computational teams on data management and processing; Contribute to strategic planning for instrumentation and facility expansion; Maintain SOPs and quality-control processes; Coordinate with vendors to maintain instrument performance
Seniority
Senior, hands-on IC with management responsibilities