Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs
Core
Develop innovative chemical and bio-conjugation processes for manufacturing hybrid modality drug candidates including antibody drug conjugates, peptide antibody conjugates, synthetic peptides, and oligonucleotides.
Role type
Senior IC process development scientist (synthetic peptides, oligonucleotides, ADCs)
Builds
Drug substance manufacturing processes and technologies for hybrid modality assets
Domain
Biopharmaceutical manufacturing / Bioconjugation chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
organic chemistry, bioconjugation chemistry, process development, synthesis, purification, cGMP manufacturing, technology transfer, process modeling, data interpretation
Preferred skills
antibody drug conjugate expertise, synthetic oligonucleotide expertise, synthetic peptide expertise, laboratory automation, analytical characterization (HIC-HPLC, SEC, LC-MS, IEX, RP-HPLC), peer-reviewed publications
Technologies
HIC-HPLC, SEC, LC-MS, IEX, RP-HPLC, laboratory automation
Responsibilities
Invent synthetic routes and develop safe, robust, sustainable, cost-effective processes for hybrid modality drug candidates; Drive technology innovation in synthesis, purification, and characterization of bioconjugates, oligonucleotides, and synthetic peptides; Support cGMP manufacturing and technology transfer to internal and external facilities; Advance enabling technologies to improve sustainability and process efficiency; Ensure process performance through modeling and characterization; Contribute to drug substance development teams with experimental results and technical updates; Work cross-functionally to deliver regulatory documents and support filings; Serve as a technical expert in bioconjugation and process chemistry; Work independently to advance projects within deadlines.
Seniority
Senior, hands-on IC