Wet Lab Scientist - Ligand Discovery in Gorgulla Lab
Core
Experimental validation of computationally predicted protein-ligand interactions and hit/lead compounds for drug discovery projects targeting cancer, epigenetic regulation, and healthy aging.
Role type
Senior Wet Lab Scientist (Ligand Discovery)
Builds
High-quality recombinant proteins, validated binding assays, and experimental data for drug discovery pipelines.
Domain
Biophysics / Structural Biology / Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
High-throughput binding assays and screening automation, Surface Plasmon Resonance (SPR), Plate-based fluorescence assays (FP, TR-FRET), Biophysical/biochemical binding technologies (BLI, MST, ITC, AlphaScreen), Protein expression and purification (bacterial, insect, mammalian), Assay development and optimization, Lab management
Preferred skills
Structural biology methods (cryo-EM, X-ray crystallography), Membrane protein/multi-domain protein expertise, Liquid-handling robot operation
Technologies
SPR, MST, ITC, BLI, FP, TR-FRET, HTRF, NMR, X-ray, cryo-EM, liquid-handling robots, plate readers
Responsibilities
Design and execute binding assays for ligand discovery, produce high-quality recombinant proteins, optimize workflows for high-throughput screening, manage day-to-day operations of the wet lab, mentor junior scientists and students
Seniority
Senior, hands-on IC with lab management responsibilities