Senior Scientist I, siRNA Pipeline Development & Targeted Delivery
Core
Designing and executing experimental approaches to advance siRNA-based pipeline development and targeted delivery platforms for novel RNA-based therapeutics.
Role type
Senior Scientist I, siRNA Pipeline Development & Targeted Delivery
Builds
Novel RNA-based therapeutics (siRNA) and targeted delivery platforms
Domain
Biopharmaceuticals / siRNA / Drug Delivery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
siRNA candidate nomination, pipeline development, drug delivery platforms, receptor biology, targeted delivery, uptake assays, trafficking assays, functional delivery assays, molecular biology, RNA biology, cell culture, RNA extraction, RT-qPCR, ddPCR, NGS library preparation, protein assays (ELISA, Western Blot, JESS), flow cytometry, biomarker quantification, assay development, high-throughput screening, mechanism of action studies, biodistribution analysis
Preferred skills
assay troubleshooting, sensitivity enhancement, reproducibility optimization, throughput improvement
Technologies
RT-qPCR, ddPCR, NGS, ELISA, Western Blot, JESS, Flow Cytometry
Responsibilities
Lead research efforts to advance new therapeutic targets for siRNA-based pipeline development; Design and execute in vitro and in vivo proof-of-concept studies for novel extrahepatic, targeted siRNA delivery platforms; Design and execute receptor expression profiling, ligand–receptor binding, internalization, and trafficking assays; Evaluate functional delivery and target knockdown in receptor-positive cells and tissues; Provide scientific leadership and expertise in candidate nomination and pipeline development; Mentor and support junior scientists within the team.
Seniority
Senior, hands-on IC