Senior Scientist I, siRNA Pipeline Development & SAR Optimization
Core
Designing and executing experimental approaches to advance siRNA-based pipeline development, including lead optimization and candidate nomination for RNA-based therapeutics.
Role type
Senior Scientist I, siRNA Pipeline Development & SAR Optimization
Builds
Novel RNA-based therapeutics for patient care
Domain
Biopharmaceuticals / siRNA therapeutics / Genetic Medicine
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
siRNA library design, SAR studies, sequence optimization, chemical modification patterns, conjugation sites, linkers optimization, molecular biology, RNA biology, cell culture, RNA extraction, RNA quantification, NGS library preparation, protein assays, flow cytometry, assay development, high-throughput screening
Preferred skills
ex-hepatic delivery of siRNA, mechanism of action studies, biodistribution analysis, biomarker analysis
Technologies
RT-PCR, qPCR, ddPCR, NGS, ELISA, Western Blot, JESS, flow cytometry
Responsibilities
Lead research efforts to advance new therapeutic targets for siRNA-based pipeline development; Design and execute in vitro and in vivo proof-of-concept studies to evaluate siRNA library and characterize lead compounds; Design and execute structure-activity-relationship (SAR) studies for lead optimization; Provide scientific leadership and expertise in candidate nomination and pipeline development; Mentor and support junior scientists within the team
Seniority
Senior, hands-on IC