Senior Scientist, Bioanalytical Sciences
Core
Lead the development, qualification, and implementation of immunogenicity and ligand binding assays (LBA) to support gene therapy platform and therapeutic programs, with a focus on characterizing innate immune responses to nucleic acid modalities.
Role type
Senior Scientist, Bioanalytical Sciences (Innate Immunity, Ligand Binding Assays & Flow Cytometry)
Builds
Bioanalytical assays for innate immunogenicity, ligand binding assays (LBA), and biodistribution studies for LNP-formulated nucleic acid therapeutics.
Domain
Biotechnology / Gene Therapy / Innate Immunology
Required skills
Innate immune signaling expertise, Nucleic acid sensing pathway knowledge, Multicolor flow cytometry, ddPCR, Ligand binding assays (LBA), Leukopak processing, PBMC isolation, LNP/nucleic acid therapeutic experience, Bioanalytical method development, Junior scientist management
Preferred skills
Experience with LNP delivery of nucleic acid cargoes, Experience developing bioanalytical methods for drugs and biomarkers
Technologies
Flow Cytometry, ELISA, MSD, Luminex, bDNA, ddPCR
Responsibilities
Design, develop, and execute cell-based immunoassays, flow cytometry assays, and LBAs to assess immunogenicity; Establish in vitro screening assays for nucleic acid modalities; Collaborate with CMC and molecular biology teams to screen nucleic acid cargoes; Ensure development and validation of bioanalytical assays in compliance with guidelines; Design and execute biodistribution studies; Execute test procedures including sample extraction and measurement; Analyze and summarize scientific data; Mentor and manage junior scientists
Seniority
Senior, hands-on IC with mentorship responsibilities