Scientist / Senior Scientist, tLNP Formulation and Delivery
Core
Design, formulate, and characterize targeted lipid nanoparticles (tLNPs) to enable extrahepatic tissue tropism for AI-designed genetic medicines.
Role type
Senior Scientist, tLNP Formulation and Delivery (via careerplan.io/jobs/34860acf-8bd7-44d0-b970-193487828e70-scientist-senior-scientist-tlnp-formulation-and-delivery-at-basecamp-research)
Builds
Targeted lipid nanoparticles (tLNPs) for in vivo cell and gene therapies
Domain
Biotechnology / Gene Therapy / Drug Delivery
Required skills
LNP assembly (microfluidic/NanoAssemblr), bioconjugation chemistry, lipid compositional optimization, DLS/zeta potential/encapsulation assays, in vitro assay development (flow cytometry/FACS), in vivo study design
Preferred skills
High-throughput screening, Design of Experiments (DoE) software, AI-guided formulation, peptide-based targeting ligands, LNP scale-up
Technologies
NanoAssemblr, T mixing, ethanol injection, dynamic light scattering, RiboGreen assays, JMP
Responsibilities
Design and execute tLNP formulations with varying lipid ratios and structures; perform surface modifications to attach targeting moieties; conduct physicochemical characterization and analytics; develop in vitro assays for cellular uptake and endosomal escape; design in vivo biodistribution and PK studies; maintain ELN records and author technical reports.
Seniority
Senior, hands-on IC
