Senior Scientist, Small Molecule Screening
Core
Designing, constructing, and validating DNA-encoded small molecule libraries to discover novel therapeutics for healthcare and sustainability.
Role type
Senior Scientist, Small Molecule Screening (DNA-encoded library focus)
Builds
Novel platform technology for small molecule drug discovery
Domain
Biotechnology / Small molecule drug discovery / DNA-encoded libraries
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
DNA-encoded library (DEL) design and synthesis, affinity-based selection, hit deconvolution and validation, DNA-compatible chemistry, off-DNA resynthesis, biochemical/biophysical assays, CRO management
Preferred skills
Cheminformatics, library enumeration, chemical space analysis, droplet-based screening, microfluidics, laboratory automation
Technologies
Next-generation sequencing, LC-MS, split-and-pool combinatorial synthesis, enzymatic ligation
Responsibilities
Design and construct DNA-encoded small molecule libraries; Execute and optimize affinity-based selections against protein targets; Deconvolute and validate screening hits; Optimize workflows and establish best practices; Translate experimental data into insights; Present results at team meetings
Seniority
Senior, hands-on IC with technical direction ownership