Senior Scientist, Protein Engineering
Core
Design, construct, and test large-scale protein variant libraries to build a novel platform technology for small molecule drug discovery.
Role type
Senior Scientist, Protein Engineering (Hands-on IC)
Builds
Novel platform technology for small molecule drug discovery
Domain
Biotechnology / Protein Engineering / Drug Discovery
Deliverable
production ML models | product features | research
Required skills
Deep mutational scanning, library-scale mutagenesis, protein display systems (yeast/mammalian/phage), FACS, next-generation sequencing (NGS), protein expression and purification, biochemical/biophysical assay development
Preferred skills
Machine learning for protein engineering, statistical analysis of variant fitness landscapes
Technologies
Illumina, PacBio, Greenhouse
Responsibilities
Design and construct large-scale protein variant libraries; Establish and optimize display, selection, and sorting workflows; Assess library quality and validate outputs via biochemical/biophysical characterization; Optimize workflows and establish best practices; Translate experimental data into insights and present results
Seniority
Senior, hands-on IC