Senior Scientist, Protein Engineering
Core
Design, engineer, and optimize novel membrane protein constructs to build a high-throughput peptide screening platform for next-generation therapies.
Role type
Senior Scientist, Protein Engineering (IC)
Builds
Novel membrane protein constructs and DNA/oligo libraries for pooled screening
Domain
Biotechnology / Protein Engineering / Membrane Proteins
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Membrane protein construct design, Molecular biology, Plasmid engineering, Lentiviral transduction, Mammalian cell culture, Secretory pathway knowledge, First-principles design
Preferred skills
Computational protein design (Rosetta, AlphaFold-Multimer, RFdiffusion, ProteinMPNN), Flow cytometry, Synthetic gene/oligo-pool design, High-throughput screening design, Electronic lab notebooks (Benchling)
Technologies
Rosetta, AlphaFold-Multimer, RFdiffusion, ProteinMPNN, FlowJo, Benchling
Responsibilities
Design and troubleshoot membrane protein constructs across diverse architectures; Perform molecular biology and plasmid engineering at scale; Design and run assays to characterize construct expression and performance; Optimize workflows and establish best practices; Partner with screening colleagues to ensure constructs are fit for downstream selection; Translate experimental data into insights and shape scientific strategy.
Seniority
Senior, hands-on IC