Senior Scientist, Degrader Antibody Conjugate Cellular Pharmacology
Core
Define and drive in vitro screening and pharmacological characterization for Degrader Antibody Conjugates (DACs) to advance targeted protein degradation candidates for cancer and inflammatory diseases.
Role type
Senior Scientist, Cellular Pharmacology (DAC/ADC)
Builds
In vitro screening frameworks and mechanistic pharmacology data packages for DAC candidates
Domain
Biopharmaceuticals / Targeted Protein Degradation / Oncology / Immunology
Required skills
Preclinical drug discovery workflow for ADCs/DACs, in vitro assay design and execution, cell-based assay development, mammalian cell line cultivation, target engagement analysis, mechanism of action assessment, cross-functional leadership
Preferred skills
Experience manipulating cell surface antigens, engineering reporter cell lines, automated workflow implementation
Technologies
Automated workflows, cell-based assay platforms
Responsibilities
Design and execute pharmacology studies to assess biological activity and mechanism of action of lead molecules; Develop and perform cell-based assays to characterize DAC and biologic activity including antigen binding and targeted protein degradation; Cultivate and maintain mammalian cell lines; Lead and influence a matrixed, cross-functional organization to advance multiple programs in parallel; Serve as a key scientific decision-driver for DAC in vitro pharmacology; Design, build, and drive the in vitro pharmacology and screening framework from primary screening through mechanistic characterization.
