Oligo Discovery Biology Principal Scientist
Core
Lead in vitro screening of oligonucleotides (siRNA, ASO, SSO, RNA editing) to evaluate activity and specificity for vaccine and medicine discovery.
Role type
Principal Scientist, Oligo Discovery Biology
Builds
Cell-based assays and experimental data supporting portfolio and platform projects
Domain
Biopharma, Oligonucleotide therapeutics, Molecular biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Cell and molecular biology, Oligonucleotide biology (siRNA, ASO, SSO, RNA editing), Cell-based assay development, RNA isolation, qPCR, Primary and immortalized cell culture
Preferred skills
Protein evaluation (Western blot, ELISA), High-throughput screening, Method transfer to CROs, Adipose cell modeling, Scientific publications/patents
Technologies
qPCR, Western blot, ELISA, siRNA, ASO, SSO, RNA editing
Responsibilities
Design and execute cell and molecular biology experiments; Establish robust cell-based assays; Analyze and present experimental data; Lead cross-functional discussions; Mentor early-career scientists
Seniority
Principal, hands-on IC with mentorship