Scientist, Oligonucleotide Synthesis
Core
Establish pre-clinical capabilities for oligonucleotide synthesis (ASOs, siRNA, SSO, RNA editors) using high-throughput automation and next-generation chemistry.
Role type
Scientist, Oligonucleotide Synthesis
Builds
Pre-clinical oligonucleotide synthesis workflows and method development
Domain
Biopharma / Oligonucleotide therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Oligonucleotide synthesis (SPOS), Laboratory automation platforms (Lynx, Fluent), High-throughput synthesizers (Mermade, Dr. Oligo), LC/HRMS analytics, RNA therapeutics biology
Preferred skills
Oligonucleotide conjugation chemistries, Troubleshooting complex chemical challenges
Technologies
Lynx, Fluent, Mermade 192X, Dr. Oligo 192 XLc, LC/HRMS, UPHLC
Responsibilities
Support pre-clinical high-throughput and mid-scale synthesis of ASOs, siRNA, SSO, and RNA editors; Maintain high-throughput automation workflows; Develop and maintain SOPs for synthesis, processing, and purification; Collaborate with analytical and delivery chemistry teams
Seniority
Mid-level Scientist