Scientist, Oligonucleotide Sciences Analytical Chemistry
Core
Develop and execute advanced analytical methods for the separation, identification, and quantification of synthetic oligonucleotide therapeutics to support pre-clinical pipeline analysis and quality control.
Role type
Scientist, Oligonucleotide Discovery Analytical Chemistry
Builds
High-throughput oligonucleotide production platform and in-house synthesis support
Domain
Biopharmaceuticals / Oligonucleotide therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
LC/MS(-MS) methodology, mass spectrometry data analysis, method development, method troubleshooting, synthetic oligonucleotide characterization
Preferred skills
high-resolution LC/MS data acquisition, high-throughput LC/MS, reverse phase/ion-pairing chromatography, anion exchange chromatography, size-exclusion chromatography, hydrophilic interaction chromatography, NMR, X-ray crystallography, UV/Vis spectrophotometry, circular dichroism
Technologies
LC/MS, NMR, X-ray crystallography, UV/Vis spectrophotometry, circular dichroism
Responsibilities
Operate validated analytical methods for high-throughput oligonucleotide production; Develop robust analytical methods for novel chemistries and conjugates; Characterize novel synthetic oligonucleotides in low- and high-throughput settings; Support analytical investigations and root cause analysis; Collaborate on project teams to represent Oligonucleotide Discovery Analytical Chemistry
Seniority
Mid-level Scientist (5+ years BS or 4+ years MS)
