Senior Scientist I, Analytical Development - Mass Spectrometry tLNP CMC
Core
Develop LC-MS methods to characterize mRNA, oligonucleotides, and LNP particles for biotherapeutic drug development.
Role type
Senior Scientist I, Analytical Development (Mass Spectrometry)
Builds
Analytical methods and characterization data for tLNP therapeutics
Domain
Biopharmaceuticals / mRNA / Lipid Nanoparticles
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
LC-MS method development, mass spectrometry operation and troubleshooting, sample preparation, regulatory document authoring, data analysis software proficiency
Preferred skills
mRNA 5' capping and 3' polyA tail analysis, antibody and LNP analysis experience, additional analytical techniques for mRNA or LNP
Technologies
Orbitrap, TOF, XCalibur, Protein Metrics, FreeStyle, Skyline, BioPharma Finder, MassLynx
Responsibilities
Operate and maintain LC-MS platforms, execute characterization activities for mRNA critical quality attributes, provide analytical support to cross-functional teams, develop innovative LC-MS techniques, conduct sample preparation and analyses, author regulatory submission documents
Seniority
Senior, hands-on IC