Principal Scientist, Oligonucleotide Analytical Chemistry
Core
Develop and execute advanced analytical methods for the analysis and quality control of pre-clinical oligonucleotide therapeutics.
Role type
Principal Scientist, Oligonucleotide Analytical Chemistry
Builds
Pre-clinical oligonucleotide therapeutics pipeline
Domain
Biopharmaceuticals / Oligonucleotide therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
High-resolution LC/MS(-MS) methodology, Mass spectrometry data analysis for biopolymers, LC/MS method development, LC/MS troubleshooting, Oligonucleotide synthesis chemistry
Preferred skills
PhD in analytical chemistry, High-throughput LC/MS data acquisition, NMR analysis, X-ray crystallography, UV/Vis spectrophotometry, Circular dichroism, In vitro biology, DMPK, Drug delivery
Technologies
LC/MS, MS, NMR, X-ray crystallography, UV/Vis spectrophotometry, Circular dichroism
Responsibilities
Develop and deploy robust analytical methods for oligonucleotide synthesis, Characterize novel synthetic oligonucleotides using LC/MS-MS, Design and manage key data pipelines, Support analytical investigations and root cause analysis, Mentor and train junior team members
Seniority
Principal, hands-on IC with mentorship
