Principal Research Scientist I (Analytical R&D for LNP and Small Molecule)
Core
Lead analytical R&D projects for New Chemical Entities (NCEs) drug substance and product in preclinical and clinical programs, focusing on impurity profiling and method development.
Role type
Principal Research Scientist (Analytical R&D)
Builds
Analytical methods and strategies for drug substance and product development
Domain
Pharmaceutical R&D, Analytical Chemistry, Lipid Nanoparticles (LNP), Small Molecules
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Analytical chemistry expertise, Impurity profiling, Method development and troubleshooting, Mass spectrometry (MS) instrumentation, HPLC/UPLC/GC/DSC/TGA/DVS/PXRD/NMR, Formulation design principles, Preclinical and clinical development knowledge
Preferred skills
Lipid nanoparticle (LNP) expertise, Synthetic molecules in solid oral dosage forms, Structure elucidation, Trace quantitation
Technologies
HPLC, UPLC, GC, DSC, TGA, DVS, PXRD, NMR, Mass Spectrometry (MS)
Responsibilities
Apply analytical separation and detection modes for complex impurity profiling, Generate and lead new scientific proposals, Anticipate and evaluate scientific or regulatory advances, Demonstrate scientific initiative and creativity in R&D activities, Foster collaborations within global Analytical R&D and cross-functional partners, Understand and comply with safety, quality, and regulatory policies
Seniority
Principal, hands-on IC with strategic leadership