Principal Research Scientist I, In Vivo CAR-T Biology
Core
Define original scientific hypotheses and R&D strategies for novel in vivo CAR T-cell therapies, advancing them from concept through IND-enabling studies.
Role type
Principal Research Scientist I (In Vivo CAR-T Biology)
Builds
Next-generation in vivo CAR T-cell therapies
Domain
Immuno-oncology / Cell therapy / Synthetic biology
Required skills
CAR-T discovery research, cell therapy, immuno-oncology, designing and generating CAR-T candidates, preclinical evaluation, synthetic biology, T-cell biology, developing complex experimental workflows, functional screening assays, Principal Investigator leadership, project management
Preferred skills
Next-generation in vivo lentiviral CAR-T platforms
Technologies
Lentiviral vectors, CAR constructs, mRNA-tLNP (contextual collaboration)
Responsibilities
Define research and development strategies for novel in vivo CAR T-cell therapies; Anticipate and critically evaluate scientific advances or competitive threats; Collaborate with Quantitative Medicine, Biotherapeutics, Genetic Medicine, and Discovery Research mRNA-tLNP groups; Lead laboratory project execution by translating therapeutic hypotheses into actionable plans; Mentor/supervise a team of one or more; Primary author of novel workflows, publications, presentations, regulatory documents and/or primary inventor of patents
Seniority
Principal, strategy & mentorship