Senior Scientist II, Biotransformation and Disposition
Core
Design, execute, and interpret in vitro and in vivo biotransformation and ADME studies to support drug discovery and development programs.
Role type
Senior Scientist II, Biotransformation and Disposition
Builds
In vitro and in vivo biotransformation studies, metabolite profiling, and structural elucidation data for drug candidates.
Domain
Pharmaceutical R&D, Drug Metabolism and Pharmacokinetics (DMPK)
Required skills
Drug metabolism, metabolite profiling, mass spectrometry, liquid chromatography, structure elucidation, analytical method development, cross-functional collaboration, regulatory compliance, laboratory safety
Preferred skills
Peptide chemistry, structural elucidation of peptides, high-resolution mass spectrometry, automation approaches, emerging technologies
Technologies
LC-MS/MS, high-resolution mass spectrometry, Thermo mass spectrometers, Sciex mass spectrometers (via careerplan.io/jobs/3743990015917046-senior-scientist-ii-biotransformation-and-disposition-at-abbvie)
Responsibilities
Design and conduct biotransformation studies to identify metabolites and clearance mechanisms; Develop and optimize chromatographic and mass spectrometric methods; Integrate metabolite data with DMPK, ADME, and toxicology findings; Represent the team on cross-functional project teams; Evaluate and implement emerging technologies and automation approaches; Mentor colleagues and share technical expertise
Seniority
Senior, hands-on IC with mentoring responsibilities
