Scientist, DMPK
Core
Enable efficient drug discovery and development of siRNA and other therapeutic candidates by characterizing ADME and PK/PD relationships through quantitative pharmacology and modeling.
Role type
Scientist, DMPK (Quantitative Pharmacology)
Builds
Quantitative models and simulations for drug disposition and exposure–response relationships
Domain
Biopharmaceuticals / siRNA therapeutics / Pharmacokinetics
Deliverable
production ML models | dashboards & analysis
Required skills
quantitative pharmacology, PK/PD modeling, ADME analysis, non-compartmental analysis, compartmental PK/PD, PBPK, mechanistic/systems modeling, data integration, model building and qualification, regulatory reporting
Preferred skills
experience with siRNA modalities, cross-functional collaboration, staying current with emerging modeling methodologies
Technologies
Phoenix WinNonlin, Monolix, R
Responsibilities
Design, execute, and interpret in vitro and in vivo ADME and PK/PD studies; Apply quantitative pharmacology approaches to characterize drug disposition; Integrate PK, PD, and biomarker data to inform candidate selection and dose projection; Build, qualify, and document models and simulations; Contribute to the design of preclinical and translational studies; Collaborate with cross-functional teams to analyze data and communicate insights; Prepare clear, well-documented analyses, reports, and presentations for regulatory submissions.
Seniority
Individual Contributor