Principal Scientist, DMPK
Core
Lead DMPK strategies and studies for oligonucleotide therapeutics and emerging modalities from discovery through clinical development.
Role type
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
Builds
Oligonucleotide therapeutics and other drug modalities
Domain
Biopharmaceuticals / Drug Discovery and Development
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
DMPK strategy development, ADME characterization, PK/PD analysis, translational pharmacology, regulatory submission preparation, quantitative modeling and simulation, cross-functional collaboration, scientific mentorship, project management
Preferred skills
Oligonucleotide therapeutics experience (RNAi, ASO, conjugates), population PK/PBPK modeling, regulatory health authority interactions
Technologies
None explicitly stated
Responsibilities
Develop and implement DMPK strategies for discovery and clinical development; Design and execute DMPK studies to characterize ADME and PK/PD relationships; Collaborate with research scientists to optimize tissue delivery and candidate selection; Partner with Toxicology, Clinical Pharmacology, and Regulatory Affairs to integrate data for development decisions; Apply modeling and simulation for dose prediction and translation; Lead preparation of DMPK reports and regulatory submission content (CTA, IND, NDA); Provide scientific mentorship to junior scientists; Manage multiple programs and priorities in a fast-paced environment; Present scientific findings to project teams, management, and regulatory agencies
Seniority
Principal, strategic leadership and hands-on scientific contribution
