Scientist, Metabolomics
Core
Design and apply LC-MS/MS methods for endogenous metabolite and lipid quantification to identify biomarkers and characterize pharmacodynamic activity of RNAi-based therapeutics.
Role type
Scientist, Metabolomics
Builds
Biomarker discovery and target validation data for RNAi therapeutics
Domain
Biotechnology / Metabolomics / Mass Spectrometry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
LC-MS/MS method development and validation, endogenous metabolite/lipid sample preparation, bioinformatics data analysis, statistical analysis, assay design, electronic lab notebook management
Preferred skills
Triple-quadrupole and high-resolution accurate mass LC-MS/MS experience, Python or R programming, AI-based coding tools, stable isotope tracing, metabolic flux analysis
Technologies
Sciex QTRAP, Thermo Orbitrap, Python, R
Responsibilities
Design and validate LC-MS/MS methods for metabolite/lipid quantification; Perform end-to-end sample preparation for biofluids, tissues, and cells; Operate and troubleshoot LC-MS systems; Develop bioinformatics tools for data processing; Identify and onboard novel technologies; Maintain QC records and document protocols; Collaborate on preclinical/clinical study design; Present results and author manuscripts
Seniority
Senior, hands-on IC
