Senior Scientist I, siRNA Therapeutics – Oncology
Core
Lead in vitro discovery biology efforts to support the development of innovative siRNA-based medicines for oncology.
Role type
Senior Scientist I, siRNA Therapeutics
Builds
siRNA-based therapeutic candidates for oncology
Domain
Biopharmaceuticals / Oncology / RNA Interference
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
RNA interference (RNAi) biology, in vitro siRNA discovery, assay development and optimization, siRNA screening, lead optimization, mechanism-of-action studies, mammalian cell culture, transfection techniques, molecular biology techniques (stem-loop RT-qPCR, RT-qPCR), data analysis, critical thinking
Preferred skills
tumor intrinsic biology, immune oncology, tumor models, extrahepatic oligonucleotide delivery technologies (antibody–oligonucleotide conjugates), publication track record
Technologies
96 well RNA isolation, qPCR, westerns, ELISA, flow cytometry, reporter assays, RNA-seq, microscopy
Responsibilities
Design and execute experiments for target validation, assay development, and siRNA screening; Identify and resolve key biological and technical pitfalls related to siRNA activity, delivery, and stability; Author internal technical reports, regulatory documents, conference proceedings, manuscripts, and patents
Seniority
Senior, hands-on IC