Senior Scientist I, Cell Therapy Discovery
Core
Lead CAR construct design, T-cell engineering, and in vitro functional characterization to advance cell therapy programs from discovery toward translation.
Role type
Senior Scientist I, Cell Therapy Discovery
Builds
Engineered CAR-T cell therapies and functional assays
Domain
Biotechnology / Cell Therapy / Immunology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Human T-cell isolation and culture, Lentiviral transduction and electroporation, Flow cytometry panel design and analysis, Functional assays (target killing, cytokines, proliferation), Molecular methods (PCR/qPCR, NGS prep), Assay development and optimization
Preferred skills
Advancing CAR-T candidates to preclinical packages, Closed-system scale-up evaluations, Experience with armored/logic-gated/in vivo CARs
Technologies
ELN, FlowJo, GraphPad, qPCR, NGS
Responsibilities
Lead CAR construct design and engineering; characterize activity of engineered cell therapies using human primary cells; develop and optimize functional assays; apply data-driven approach to experimental design and decision-making; present results and recommendations to cross-functional teams
Seniority
Senior, hands-on IC with mentorship