Scientist II – Oligonucleotide Process Development, Manufacturing Development and Scale-Up
Core
Execute, research, develop, and optimize solid-phase oligonucleotide synthesis processes from early feasibility through scale-up to GMP production.
Role type
Scientist II, Oligonucleotide Process Development and Scale-Up
Builds
Solid-phase oligonucleotide synthesis cycles and GMP production batches for diagnostics and medical devices
Domain
Healthcare diagnostics / Organic chemistry / Process engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Solid-phase oligonucleotide synthesis (phosphonamidite chemistry), Automated synthesizer operation, LC/MS characterization, Impurity identification and quantification, Process troubleshooting, Technical documentation
Preferred skills
GMP/API manufacturing experience, Waters LC/MS systems operation, Scale-up and tech transfer, Downstream purification operations, Design of Experiments (DoE)
Technologies
Cytiva ÄKTA oligoyne, Oligopolist, GE/Cytiva flow-through platforms, UPLC, IEX-HPLC, RP-HPLC, LC/MS, MassLynx, UNIFI, JMP, Minitab
Responsibilities
Design and execute solid-phase oligonucleotide syntheses on automated synthesizers; Develop, optimize, and document synthesis cycles; Support scale-up from process development to GMP production batches; Synthesize complex modified oligonucleotides; Characterize crude and purified product by analytical UPLC, IEX-HPLC, RP-HPLC, and LC/MS; Troubleshoot synthesis failures and impurity profiles; Author and review technical documents; Partner cross-functionally with Analytical Development, Downstream Processing, Quality, Manufacturing, and Regulatory teams; Maintain a safe, clean, and compliant lab environment
Seniority
Mid-level Scientist (4+ years experience)