Research Scientist, RNA Therapeutics
Core
Lead the translation of RNA and lipid nanoparticle (LNP) processes from benchtop protocols into a miniaturized, automated manufacturing platform for the ARPA-H GIVE program.
Role type
Process Development Scientist (RNA Therapeutics)
Builds
Automated continuous manufacturing platform for RNA–lipid nanoparticle drug products
Domain
Biopharmaceuticals / RNA Therapeutics / Continuous Manufacturing
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
RNA process development, in vitro transcription, RNA purification, LNP formulation, unit operation optimization, design of experiments, analytical monitoring, technology transfer
Preferred skills
GMP environment experience, microfluidic/automated processing systems, lipid nanoparticle physicochemical characterization, computational skills for data analysis and instrument automation
Technologies
HPLC, capillary electrophoresis, dynamic light scattering, zeta potential, Raman spectroscopy, tangential flow filtration, nanoprecipitation
Responsibilities
Develop and optimize RNA and LNP unit operations for continuous manufacturing; Translate benchtop processes into miniaturized and automated formats; Define critical process parameters and in-process controls; Execute design-of-experiment studies to establish operating ranges; Perform analytical and in-line process monitoring; Author and maintain process documentation
Seniority
Senior, hands-on IC with potential management responsibilities