Postdoctoral Research Fellow
Core
Conducting translational research to develop novel therapeutic strategies for Familial Dysautonomia (FD) using gene editing and small-molecule splicing modulators in mouse models.
Role type
Postdoctoral Research Fellow (Translational Neuroscience)
Builds
Therapeutic strategies for rare neurodegenerative diseases
Domain
Neuroscience / Gene Therapy / Rare Diseases
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Molecular biology techniques (DNA/RNA/protein isolation, RT-PCR, western blotting), Genetic methodologies (cloning, CRISPR/Cas editing, genomic sequencing), Cell culture (transfection, propagation, phenotypic characterization), Rodent model handling, Histological and immune-histochemical techniques
Preferred skills
Experience with behavioral assays in mouse models, Microscopy imaging, First or co-first author on peer-reviewed publications
Technologies
CRISPR/Cas, qRT-PCR, Western Blotting, IHC, Histology
Responsibilities
Design and conduct in vivo efficacy studies for gene editing strategies and compounds, Perform downstream analyses (RNA/protein quantification, splicing analysis, histology), Lead development of therapeutic delivery and molecular assays, Collaborate with researchers and mentor junior members, Prepare manuscripts and grant applications
Seniority
Postdoctoral Fellow, independent researcher