Effect of alpha-synuclein aggregates in synaptic dysfunction in the basal ganglia: identification and modulation of novel molecular targets
Core
Investigate the effects of alpha-synuclein aggregates on synaptic function in the basal ganglia (striatum) using murine models.
Role type
Research scientist (neuroscience)
Builds
Research findings on molecular targets and therapeutic strategies
Domain
Neuroscience / Neurodegenerative diseases
Deliverable
research
Required skills
murine model handling, stereotaxic surgery, electrophysiology (patch-clamp), brain slice preparation, pharmacological modulation
Preferred skills
synaptic transmission analysis, plasticity assessment, target validation
Technologies
patch-clamp, stereotaxic apparatus
Responsibilities
Perform intracerebral inoculation of alpha-synuclein, conduct electrophysiological recordings in brain slices, apply pharmacological modulation to identify molecular targets
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