Effect of alpha-synuclein aggregates in synaptic dysfunction in the basal ganglia: identification and modulation of novel molecular targets

## Responsibilities - Investigate the effects of alpha-synuclein aggregates on synaptic function in the basal ganglia, with a focus on the striatum, using murine models. - Perform intracerebral inoculation of alpha-synuclein using stereotaxic techniques. - Apply electrophysiological approaches, mainly patch-clamp recordings in brain slices, to assess alterations in synaptic transmission and plasticity. - Conduct pharmacological modulation across different experimental phases to identify and validate novel molecular targets and potential therapeutic strategies. ## Requirements - Expertise in neurobiology, particularly in synaptic function and basal ganglia research. - Proficiency in murine models and stereotaxic techniques. - Strong background in electrophysiological methods, including patch-clamp recordings in brain slices. - Experience with pharmacological modulation and molecular target identification. - Ability to design and execute complex experimental protocols. ## Nice to Have - Experience with in vivo models of neurodegenerative diseases. - Familiarity with molecular and cellular mechanisms of synaptic dysfunction. - Knowledge of therapeutic strategies for neurodegenerative disorders. ## Benefits - Opportunity to contribute to cutting-edge research in neurodegenerative diseases. - Collaborative environment with interdisciplinary teams. - Potential for publication and presentation of findings.