Medicinal Chemistry Senior Principal Research Scientist
Core
Provide scientific leadership in the design and optimization of small-molecule therapeutics across discovery programs, advancing high-quality drug candidates from early discovery through candidate selection.
Role type
Senior Principal Research Scientist (Medicinal Chemistry)
Builds
Small-molecule drug candidates
Domain
Biotechnology / Medicinal Chemistry
Required skills
Small-molecule drug discovery, SAR interpretation, structural biology integration, DMPK data integration, pharmacology data integration, safety data integration, cross-functional team leadership, strategic planning, technical mentorship
Preferred skills
None stated
Technologies
None stated
Responsibilities
Lead medicinal chemistry strategy for small-molecule discovery programs; Design, prioritize, and guide synthesis of novel compounds to optimize potency, selectivity, pharmacokinetics, and developability; Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data to drive compound design and progression; Partner closely with biology, DMPK, toxicology, and pharmaceutical sciences to advance program goals; Provide technical and strategic leadership to internal and external chemistry resources; Provide scientific leadership, mentorship, and development support to chemistry team members; Communicate program strategy, data, risks, and recommendations to senior leadership and governance teams; Support intellectual property strategy in partnership with internal stakeholders
Seniority
Senior Principal, hands-on IC with strategic leadership