Principal Scientist I/II —CAR-T Lead
Core
Design, generate, and evaluate complex lentiviral constructs for logic-gated CAR-T approaches; perform hands-on functional testing and optimization of CAR-T cells; execute cell-line engineering to develop experimental models.
Role type
Principal Scientist I/II, CAR-T Lead (IC)
Builds
Novel CAR-T cell therapy platforms and constructs for oncology immune therapeutics
Domain
Biotechnology / Cell Therapy / Oncology
Required skills
CAR-T engineering, lentiviral construct design, ex vivo cell characterization (FACS), cytokine profiling (ELISA/MSD/Luminex), immune-cell isolation, primary human T-cell culture, experimental design, data analysis
Preferred skills
Synthetic biology principles, engineered T-cell manufacturing, computational biology partnership, in vivo pharmacology collaboration
Technologies
Lentiviral vectors, FACS, ELISA, MSD, Luminex
Responsibilities
Design and execute innovative research to advance next-generation CAR-T approaches; Design, generate, and evaluate complex lentiviral constructs for logic-gated CAR-T approaches; Perform hands-on functional testing and optimization of CAR-T cells; Execute cell-line engineering to develop fit-for-purpose experimental models; Critically analyze and integrate findings across engineering, in vitro biology, and in vivo pharmacology; Present results, project updates, and recommendations to cross-functional teams and scientific leadership.
Seniority
Principal, hands-on IC