Associate Scientist - Therapeutic Proteins - Antibody Radioconjugates Technology
Core
Conjugate antibodies with bifunctional chelates and fluorescent probes, and radiolabel them to support preclinical immunoPET and Cryo-fluorescence Tomography imaging for oncology and immuno-oncology therapeutic candidates.
Role type
Associate Scientist (Therapeutic Proteins - Antibody Radioconjugates Technology)
Builds
Zr-89 radiolabeled and fluorescently-conjugated tracers for quantitative in vivo imaging studies
Domain
Biopharmaceuticals / Radiochemistry / Preclinical Imaging
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
protein chemistry, bioconjugation, chromatographic techniques (HPLC, FPLC), mammalian cell culture, radiochemistry (Zr-89, Cu-64), analytical characterization (SE-HPLC, SDS-PAGE, Western blot, UV/Vis, radio-HPLC, radio-iTLC, gamma counting), electronic laboratory notebook management
Preferred skills
experience with DFO/DOTA chelating agents, time-critical same-day tracer preparation
Technologies
SE-HPLC, SDS-PAGE, Western blot, UV/Vis spectroscopy, radio-HPLC, radio-iTLC, gamma counting, Excel, Prism
Responsibilities
Perform bioconjugation of antibodies with bifunctional chelating agents and fluorescent probes; characterize antibody bioconjugates using analytical techniques; radiolabel bioconjugated antibodies with radionuclide isotopes and purify for same-day use; run quality control testing to verify tracer quality; maintain mammalian cell culture lines and perform cell-based assays; coordinate tracer preparation timelines with imaging scientists; maintain electronic laboratory notebooks and radiation safety records; maintain instruments and troubleshoot experimental problems
Seniority
Associate, entry-level IC
