Associate Director, R&D Chemistry, Peptidomimetics
Core
Lead the discovery of peptidomimetic antibody-conjugate drug therapeutics by combining synthetic organic, medicinal chemistry, and bioconjugation expertise to optimize in vitro and in vivo properties.
Role type
Associate Director, R&D Chemistry (Peptidomimetics)
Builds
Novel antibody-conjugated peptidomimetic therapeutics for Regeneron's drug discovery pipeline
Domain
Biopharmaceuticals / Chemical Biology / Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Peptidomimetic synthesis, SAR optimization, linker-payload synthesis, chemical biology strategies, small molecule synthesis, bioconjugation techniques, team leadership, project management
Preferred skills
Experience with non-natural amino acid incorporation, alpha-Me/N-Me peptide backbone modifications, ADME/PK/PD/toxicological evaluation, cross-functional collaboration
Technologies
None explicitly listed beyond general chemical/biological methods
Responsibilities
Supervise and manage the R&D Chemistry Peptidomimetic group, generate novel peptidomimetic drug modalities via SAR-driven approaches, troubleshoot and optimize peptide potency and stability, lead internal/external project teams, identify new strategies for linker and payload design, participate in cross-functional leadership meetings
Seniority
Senior, hands-on IC with leadership responsibilities