Principal Scientist, Peptide Therapeutics
Core
Lead the discovery and optimization of peptide therapeutics by combining hands-on synthetic chemistry with strategic oversight across the full development lifecycle.
Role type
Principal Scientist, Medicinal Chemist (Peptide Therapeutics)
Builds
Novel peptide therapeutics, peptidomimetics, and non-commercial building blocks for drug discovery
Domain
Biopharmaceuticals / Peptide Chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Solid-phase peptide synthesis (SPPS), solution-phase organic chemistry, macrocyclization, structure-based design, computational modeling (MD simulations), Multi-Parameter Optimization (MPO), high-resolution analytical techniques (HPLC, Mass Spec, NMR), library-based screening (mRNA display, AS/MS, OBOC)
Preferred skills
Experience with Schrödinger, MOE, Maestro software, AI/ML-driven sequence optimization
Technologies
Schrödinger, MOE, Maestro
Responsibilities
Execute multi-step synthesis of peptides and peptidomimetics, oversee high-resolution analysis to confirm compound identity, apply conformational analysis and computational modeling to optimize potency and stability, lead multidisciplinary project teams, supervise and mentor junior scientists
Seniority
Principal, hands-on IC with strategic oversight