Associate Director, ADC platform in Oncology Drug Discovery
Core
Lead scientific strategy for antibody-drug conjugates (ADCs) focusing on payload selection, linker design, and conjugation approaches to advance differentiated targeted therapeutics.
Role type
Associate Director, scientific strategy (ADC platform)
Builds
Next-generation ADC concepts and differentiated payload-linker platforms
Domain
Oncology drug discovery / Chemical biology
Required skills
ADC payload expertise, linker and conjugation technologies, ADC biology (tumor targeting, internalization, trafficking), program strategy, cross-functional leadership, experimental design
Preferred skills
None explicitly stated
Technologies
None explicitly stated
Responsibilities
Lead scientific strategy for ADC payload selection, linker design, and conjugation approaches; Apply deep expertise across payload classes, mechanisms of action, potency, resistance biology, and tolerability to guide program design; Partner with chemistry, biology, protein engineering, pharmacology, translational sciences, and CMC teams to advance next-generation ADCs; Evaluate and prioritize novel payloads, linker technologies, and conjugation approaches for internal programs and external opportunities; Provide biology-driven insights into payload mechanism of action, tumor context, therapeutic index, and combination strategies; Design and guide experimental strategies to assess ADC activity, selectivity, resistance mechanisms, linker stability, and payload-related pharmacology; Contribute to next-generation ADC platform strategy, including differentiated payload-linker concepts and biology-aligned ADC design; Represent payload/linker expertise in cross-functional project teams, governance discussions, and external collaborations; Monitor scientific, clinical, competitive, and IP landscapes related to ADC payloads, linkers, and emerging targeted modalities; Mentor scientists and contribute to a collaborative, high-performing research environment
Seniority
Associate Director, hands-on IC with strategic leadership