Senior Principal Scientist, Peptide Therapeutics
Core
Lead medicinal chemistry efforts to optimize and advance novel peptide therapeutics from concept to clinical development.
Role type
Senior Principal Scientist (Medicinal Chemist)
Builds
Novel peptide therapeutics and peptidomimetics
Domain
Biopharmaceuticals / Peptide Therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
complex molecule organic synthesis, automated solid-phase peptide synthesis, solution-phase small molecule synthesis, high-throughput and parallel synthesis, macrocyclic peptide design, structure-activity relationship (SAR) planning, computational modeling and simulation, structure-based drug design, ligand-based drug design, mass spectrometry, HPLC, NMR analysis
Preferred skills
machine learning and AI-driven platforms for peptide property prediction, library-based screening technologies (OBOC, mRNA display, AS/MS), macrocyclic peptide properties for various routes of administration
Technologies
Schrödinger, MOE, Maestro
Responsibilities
Govern design and synthesis of innovative peptides and peptidomimetics; lead scientific and project teams from concept to clinic; implement rational drug design strategies; champion cross-functional collaboration; provide scientific leadership and mentorship; ensure data integrity and project success
Seniority
Senior, hands-on IC with leadership responsibilities
