Senior Principal Scientist, Peptide Therapeutics
Core
Lead medicinal chemistry efforts to optimize and advance novel peptide therapeutics from concept to clinical development.
Role type
Senior Principal Scientist (Medicinal Chemistry)
Builds
Novel peptide therapeutics and peptidomimetics
Domain
Biotechnology / Peptide Therapeutics
Required skills
Complex molecule organic synthesis, Automated solid-phase peptide synthesis, Solution-phase small molecule synthesis, High-throughput and parallel synthesis, Mass spectrometry analysis, HPLC analysis, NMR analysis, Rational drug design, Structure-activity relationship (SAR) planning, Macrocyclic peptide design, Computational modeling and simulation, Molecular dynamics (MD) simulations, Structure-based drug design, Ligand-based drug design, Machine learning for peptide property prediction
Preferred skills
Experience with library-based screening technologies (OBOC, mRNA display, AS/MS), Knowledge of macrocyclic peptide properties for different routes of administration
Technologies
Schrödinger, MOE, Maestro
Responsibilities
Govern the design and synthesis of innovative peptides and peptidomimetics, Lead scientific and project teams from concept to clinic, Implement rational drug design strategies, Champion cross-functional collaboration, Provide scientific leadership and mentorship, Ensure data integrity and project success
Seniority
Principal, technical leadership & mentorship