Associate Principal Scientist, In Vivo Pharmacology
Core
Develop in vivo pharmacology strategy and pharmacodynamics (PD) models for cardiometabolic, renal, and respiratory diseases to establish quantitative PK/PD relationships and preclinical proof-of-concept.
Role type
Associate Principal Scientist, In Vivo Pharmacology
Builds
Preclinical therapeutic programs and quantitative pharmacology data
Domain
Biopharmaceuticals / In Vivo Pharmacology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Quantitative pharmacology, Translational pharmacology, In vivo model development, PK/PD analysis, Target engagement studies, Assay development, Cross-functional leadership, Study design, Data interpretation, CRO management
Preferred skills
In vivo imaging techniques, Multi-modal therapeutic experience, Pharmacology lead experience
Technologies
Ultrasound, MRI, Optical imaging
Responsibilities
Define and execute in vivo model development and pharmacology strategy; Design and execute target engagement, PD, and efficacy studies; Lead model characterization and validation; Collaborate with cross-functional teams (Med Chem, DMPK, Safety); Perform quantitative data analysis and translate findings into actionable insights; Manage external partners and CROs for study execution.
Seniority
Senior, hands-on IC with strategic leadership
