Associate Director Preclinical & Translational PK/PD
Core
Develops and implements quantitative and mechanistic PK/PD models to aid in understanding target biology, therapeutic modality selection, and early clinical trial dose selection.
Role type
Associate Director, Preclinical & Translational PK/PD Modeling
Builds
Quantitative and mechanistic mathematical PK/PD models for preclinical-to-early clinical translation
Domain
Biopharmaceuticals / Pharmacokinetics & Pharmacodynamics
Deliverable
production ML models
Required skills
Mechanistic PK/PD modeling, Non-compartmental analysis, Compartmental modeling, PBPK modeling, Mathematical modeling, Simulation platforms (Phoenix NLME, NONMEM, Monolix, ADAPT, MATLAB, SimBiology), In vitro/in vivo study design, Dose selection, Therapeutic modality knowledge (antibodies, gene therapy, CAR-T, siRNAs)
Preferred skills
Biotherapeutic modalities (monoclonal/bispecific antibodies, gene therapy, CAR-T, siRNAs), Emerging therapeutic modalities
Technologies
Phoenix NLME, NONMEM, Monolix, ADAPT, MATLAB, SimBiology
Responsibilities
Develop and implement quantitative and mechanistic mathematical PK/PD models; Contribute to advancement and strategic direction of modeling and simulation sciences; Provide expert support to pre-clinical PK/PD project representatives and R&D teams; Integrate modeling and simulation analyses for multidisciplinary teams; Collaborate with Clinical Pharmacology and Quantitative Pharmacology experts; Present work at internal/external scientific meetings and publish in journals
Seniority
Senior, hands-on IC with strategic direction