Principal Scientist, Pharmacokinetics
Core
Lead Drug Metabolism and Pharmacokinetics (DMPK) efforts to guide the design and interpretation of in silico, in vitro, and in vivo analyses for novel therapeutics, assessing program risks including drug-drug interactions (DDI) and metabolism to support clinical development.
Role type
Principal Scientist, Pharmacokinetics (DMPK)
Builds
Integrated understanding of DMPK properties, PK/PD, and DDI risk profiles for small molecules, biologics, and drug conjugates.
Domain
Pharmaceutical R&D, Drug Discovery and Development
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
ADME, Bioanalytical Method Development, Biopharmaceuticals, Clinical Development, Drug Interactions, Drug Metabolism, Pharmacodynamics, Pharmacokinetics, PKPD Modeling, PBPK modeling
Preferred skills
Mentoring staff, Third-party asset evaluation, Phoenix software, SimCYP software
Technologies
Phoenix, SimCYP, PBPK modeling tools
Responsibilities
Guide design and interpretation of in silico, in vitro, and in vivo analyses; Assess program risks including DDI and metabolism; Author source reports and regulatory documents for filings; Independently evaluate and predict potential program risks; Implement strategies to address liabilities and ensure efficient program progression.
Seniority
Principal, hands-on IC with leadership and mentoring responsibilities
