Principal Scientist, Pharmacokinetics
Core
Lead drug metabolism and pharmacokinetic (DMPK) efforts for drug discovery and early clinical development across small molecules, peptides, and protein therapeutics, focusing on oncology and immunology.
Role type
Principal Scientist (Director-level equivalent), hands-on IC with management responsibilities
Builds
Drug candidates for oncology and immunology portfolios
Domain
Pharmaceutical R&D, Drug Discovery, Pharmacokinetics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
DMPK strategy design, ADME characterization, in vitro/in vivo study design, bioanalytical method development, team leadership, PK/PD data interpretation
Preferred skills
PBPK modeling, IND-enabling experience, structure-activity relationship analysis
Technologies
Phoenix WinNonlin, Berkeley Madonna, MATLAB
Responsibilities
Lead DMPK efforts across multiple modalities, characterize and optimize ADME properties, design and analyze PK/PD studies, manage a team of bioanalytical scientists, contribute to global DMPK strategy
Seniority
Principal, hands-on IC with mentorship
