Director, DMPK&M
Core
Strategic leadership for Drug Metabolism, Pharmacokinetics & Modeling (DMPK&M) across gastrointestinal and inflammatory disease programs, integrating ADME, PK/PD, and quantitative modeling to drive decisions from early discovery through clinical development.
Role type
Director, DMPK&M (Strategic IC with mentorship)
Builds
Quantitative models (PBPK, mechanistic PK/PD) and ADME strategies for IND and clinical progression
Domain
Pharmaceutical R&D, Gastrointestinal and Inflammation Therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure
Required skills
ADME strategy design, human PK prediction, PBPK modeling, regulatory submission support, cross-functional team leadership, budget management, risk mitigation (DDI, variability), mentorship
Preferred skills
Quantitative modeling & simulation frameworks, GI2 disease area expertise
Technologies
PBPK, mechanistic PK/PD, QSP tools
Responsibilities
Provide strategic leadership for DMPK&M across multiple programs; Design and execute ADME strategies supporting IND and clinical progression; Drive quantitative decision-making using modeling approaches; Identify and mitigate risks such as DDI and absorption challenges; Contribute to regulatory submissions and health authority interactions; Mentor junior scientists and foster data-driven culture
Seniority
Director, strategic leadership with mentorship
