Sr. Principal Scientist / Director, DMPK & Bioanalytical Sciences
Core
Leads DMPK and bioanalytical strategy across nonclinical and clinical programs for tRNA therapeutics, including PK study design, method development, and translational biomarker strategy.
Role type
Sr. Principal Scientist / Director, DMPK & Bioanalytical Sciences
Builds
tRNA medicines encapsulated in lipid nanoparticles (LNPs) for rare genetic diseases
Domain
Biotechnology / Rare Disease / Nucleic Acid Therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
PK study design, bioanalytical method development, mass spectrometry, ligand binding assays, multiplex immunoassays, CRO oversight, regulatory writing, team leadership
Preferred skills
LNP platform biology, rare disease therapeutics, GLP toxicology study design, LC-MS/MS platforms
Technologies
LNP, tRNA, ELISA, NGS, MSD, Luminex, LC-MS/MS
Responsibilities
Lead DMPK and bioanalytical strategy across nonclinical and clinical programs; Lead method development, qualification, and validation for bioanalytical assays; Design, execute, and oversee PK and PK-PD studies of tRNAs; Manage and qualify CRO and external lab partners; Support nonclinical toxicology programs; Analyze, interpret, and present DMPK and translational biomarker data; Author nonclinical sections of regulatory filings; Serve on the Research Leadership Team; Manage and develop direct report(s)
Seniority
Senior, hands-on IC with management responsibilities