Scientist, Process Development (Formulation)
Core
Design and execute enzyme formulation studies to support DNA template manufacturing for mRNA medicines.
Role type
Scientist, Process Development (Formulation)
Builds
Stable enzyme formulations, storage conditions, and handling instructions for DNA manufacturing workflows.
Domain
Biopharma / mRNA / Enzyme Formulation
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
protein/enzyme formulation development, stability study design, excipient compatibility assessment, analytical/biochemical/biophysical characterization, DOE and risk-based study design, troubleshooting formulation performance, technical writing and documentation
Preferred skills
DNA/nucleic acid manufacturing experience, lyophilized or frozen formulation development, high-throughput screening and automation, GMP/GLP knowledge, container-closure system familiarity
Technologies
chromatography, electrophoresis, UV/Vis, DLS, DSC/DSF, osmolality, pH, subvisible particle analysis
Responsibilities
Design and execute enzyme formulation studies to identify buffer, pH, ionic strength, stabilizer, surfactant, cryoprotectant, concentration, and storage conditions; Develop stability study designs evaluating activity, purity, degradation, aggregation, adsorption, and functional performance; Assess formulation robustness during freeze/thaw, hold time, dilution, mixing, temperature exposure, and agitation; Partner with analytical and DNA process development to define requirements and ensure manufacturability; Prepare protocols, technical reports, and transfer-ready documentation; Support implementation by providing technical rationale and troubleshooting guidance to manufacturing sciences and Quality partners
Seniority
Mid-to-Senior Scientist, hands-on IC