Scientist-II Developability & Preformulation
Core
Scientist II supporting developability assessment and preformulation for biologics, focusing on proteins, antibodies, and antibody-oligonucleotide conjugates (AOCs) to enable robust manufacturing processes.
Role type
Scientist II, hands-on IC in biologics preformulation
Builds
Formulation strategies and data packages for early-stage genetic therapy programs
Domain
Biopharmaceuticals / Genetic Medicine / Protein Therapeutics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
biologics formulation (mAbs), protein formulation technologies, stability and analytical assays, high-concentration formulation challenges, Design of Experiments (DoE)
Preferred skills
AOCs or ADCs formulation, high-throughput formulation tools, statistical/data analysis tools, therapeutic protein discovery
Technologies
Unchained Labs Big Tuna/Big Kahuna/Junior, Sartorius AMBR Crossflow, Pendotech 5TFF, Repligen KR2i, SEC, RP, CE-SDS, cIEF, DLS, DSF, MALS, mass spectrometry, JMP, GraphPad, SigmaPlot
Responsibilities
Plan and execute formulation experiments to assess and optimize stability; Establish developability profiles for candidate molecules; Identify formulation-relevant critical quality attributes; Contribute scientific recommendations regarding formulation technologies; Support cross-functional teams on product handling and storage; Prepare and review methods, protocols, and technical reports; Train and support Research Associates
Seniority
Mid-level, hands-on IC
