Senior Scientist, Discovery Biology
Core
Lead discovery of novel targeted protein degradation drugs for solid tumors by exploring disease biology and identifying novel drug targets.
Role type
Senior Scientist, Discovery Biology (Cancer Biology)
Builds
Novel targeted protein degradation drugs for solid tumors
Domain
Oncology / Cancer Biology / Protein Degradation
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Cancer biology, Genetics, In vitro cell culture, Mechanistic hypothesis formulation, Assay development, Disease modeling, Target validation, Data mining, Independent experiment design, Cross-functional collaboration
Preferred skills
Targeted protein degradation technologies, Molecular glue approaches, Preclinical solid tumor models (2D/3D spheroids, organoids, cancer stem cells), CRISPR technologies, Cloning, Publication record in cancer biology
Technologies
CRISPR, RNAi, Lentiviral expression, qPCR, Western blotting, FACS, Immunofluorescence, Live cell imaging, PRISM
Responsibilities
Formulate mechanistic hypotheses for drug discovery projects and design/execute experiments; Develop and implement cellular assays to support discovery of small molecules; Design and execute research strategies to understand mechanisms of novel compounds and targets; Develop new drug discovery projects based on literature and data mining; Collaborate with informatics and translational research teams to validate novel targets; Maintain written reports and present scientific results to multidisciplinary teams
Seniority
Senior, hands-on IC
