Senior Scientist, Translational Research (Oncology TRC)
Core
Designing and executing translational research studies to advance oncology therapeutics from candidate optimization through IND enabling activities to Clinical Proof of Concept, focusing on biomarker development, drug mechanism of action, and patient stratification.
Role type
Senior Scientist, Translational Research (Oncology)
Builds
Novel oncology therapeutics and early clinical development programs
Domain
Oncology / Immuno-oncology / Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Flow cytometry, biomarker assay development (ELISA, MSD, Luminex), in vitro oncology modeling, functional genomics (CRISPR, RNAi), cell culture, primary cell isolation, data interpretation, scientific report writing
Preferred skills
Patient-derived organoid/tumoroid culture, ex vivo manipulation, preclinical development of human blood-based biomarkers, industry experience in drug discovery
Technologies
CRISPR, RNAi, ELISA, MSD, Luminex, qPCR
Responsibilities
Develop biomarker, pharmacodynamic, and target engagement assays; execute bench studies for drug combination and indication selection; characterize oncogenic targets using functional genomics tools; interact with project teams and contract laboratories for study oversight; co-author non-clinical pharmacology reports and publications; interpret and discuss experimental data.
Seniority
Senior, hands-on IC
