Principal Scientist, Inflammation
Core
Lead discovery and translational biology efforts for a novel immune-targeting therapeutic platform focused on selective modulation of pathogenic immune-cell populations in autoimmune and inflammatory diseases.
Role type
Principal Scientist, Inflammation
Builds
Novel immune-targeting therapeutic candidates for autoimmune and inflammatory diseases
Domain
Biotechnology / Immunology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
in vitro and ex vivo immune cell assay development, mechanistic characterization, in vivo translational pharmacology, immune cell profiling, biodistribution studies, pharmacodynamic biomarker development, data integration for mechanistic insights, preclinical efficacy evaluation
Preferred skills
lymphocyte biology expertise, immune effector mechanisms, high-impact scientific publications, primary immune-cell assays, co-culture systems, immune mediated cytotoxicity, high parameter flow cytometry, preclinical mouse models, small and large molecule drug discovery, mechanism of action studies, ELISA, MSD, single-cell RNA sequencing, CRISPR/Cas9, omics data analysis
Technologies
flow cytometry, scRNA-Seq, CRISPR/Cas9, ELISA, MSD
Responsibilities
Lead in vitro and ex vivo biological strategy for immune-targeting platforms, design and execute in vivo studies evaluating lymphocyte-mediated target cell depletion, develop and optimize functional immune-cell assays, build translational biology capabilities including immune cell profiling and biomarker development, integrate in vitro and in vivo datasets to generate mechanistic insights, advance lead therapeutic candidates toward development, collaborate with cross-functional teams on laboratory experiments
Seniority
Principal, research leader with independent scientific contributions