Principal Scientist II - Pharmacology
Core
Lead in vivo anti-tumor efficacy and PK/PD studies using CDX, PDX, and syngeneic models to evaluate novel cancer therapies and inform clinical development.
Role type
Principal Scientist II, Pharmacology (Labhead)
Builds
Pre-clinical in vivo models and data for early-stage drug discovery pipeline
Domain
Oncology / Biopharmaceuticals
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
CDX/PDX xenograft tumor models, syngeneic models, antibody drug conjugates, cell culture, PCR, ELISA, western blot, flow cytometry
Preferred skills
Antibody drug conjugates expertise
Technologies
Prism, Excel
Responsibilities
Design pre-clinical in vivo studies to explore hypotheses and establish proof-of-concept; Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity and biomarkers; Manage associate-level scientists; Collaborate with cross-functional project teams; Analyze and present results within multidisciplinary teams; Adhere to animal protocols and document data in electronic laboratory notebooks
Seniority
Senior, hands-on IC with management responsibilities