Senior Scientist, Respiratory Biology (Discovery Research)
Core
Design, execute, and interpret in vitro and ex vivo studies to support target identification, validation, and mechanism-of-action research for chronic lung diseases.
Role type
Senior Scientist, Respiratory Biology (Discovery Research)
Builds
Mechanistic datasets and experimental models for early discovery programs in respiratory diseases.
Domain
Biopharmaceuticals / Respiratory Biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Respiratory biology expertise, Human primary cell culture (airway/alveolar epithelial), In vitro/ex vivo model development (ALI, organoids, PCLS), Molecular and cellular biology techniques, Flow cytometry/FACS, Imaging-based analysis (IHC, IF, confocal microscopy), Multiplex biomarker platforms (Meso Scale Discovery, Luminex, Olink, AlphaLISA), Experimental design and troubleshooting
Preferred skills
Respiratory drug discovery experience, Tissue remodeling and fibrosis research, Patient-derived respiratory tissues, Transcriptomic datasets (bulk/single-cell RNA-seq), Organoid biology, Spatial biology approaches
Technologies
ALI cultures, Organoid systems, Precision-cut lung slices (PCLS), Meso Scale Discovery, Luminex, Olink, AlphaLISA, Confocal microscopy, Flow cytometry
Responsibilities
Develop disease-relevant experimental systems, Generate mechanistic datasets on epithelial dysfunction and immune responses, Apply imaging and flow cytometry techniques, Support translational biomarker discovery, Integrate multi-omics datasets, Collaborate across biology, pharmacology, and clinical teams
Seniority
Senior, hands-on IC
