Senior Computational Biologist – Early Discovery Immunology
Core
Integrate massive datasets (phenomics, transcriptomics, genomics, proteomics) to nominate novel targets, validate disease biology, and define precision Immunology & Inflammation strategies for drug discovery.
Role type
Senior domain expert computational biologist (immunology)
Builds
Novel target data packages and early patient population hypotheses for drug discovery programs
Domain
Biotech / Pharma / Immunology and Inflammation
Deliverable
production ML models | product features
Required skills
Domain expertise in immunological diseases and target ID, Understanding of patient genetics and druggability of disease pathways, Experience applying computational methods (probabilistic, statistical, ML) to complex biological/clinical data, High-level programming in Python or R, Exceptional data visualization skills
Preferred skills
Experience building target discovery engines, Experience designing high-throughput screens with CRISPR or small molecule perturbations, Exposure to drug program advancement from proof of concept to IND
Technologies
Python, R
Responsibilities
Evaluate molecular evidence for target nomination and validation, Pilot novel methods for target discovery and disease biology validation, Define internal criteria for target data packages and early patient population strategy, Connect innovative analysis methods to platform and engineering teams, Collaborate cross-functionally to build data packages driving program milestones, Present data analysis to decision makers and stakeholders
Seniority
Senior, hands-on IC
